Title: Professor and Chair, Department of Microbiology
Institution: Mount Sinai School of Medicine
Dr. Palese is focusing on understanding the potential role of the regulatory noncoding regions of the 1918 genes, as well as the NP and P genes, in viral pathogenicity. These viral factors form the molecular replication machinery responsible for viral protein production and therefore are a critical limiting step in the rate of generation of infectious virus particles. The potential role in virulence of the newly discovered pro-apoptotic influenza virus-encoded protein, PB1-F2, is also being analyzed. Pathogenicity studies are performed in close collaboration with Drs. Katze and Tumpey. In addition to providing one more piece of the puzzle required for understanding the virulence of the 1918 virus, this project is critical to all project components that use live influenza virus recombinants containing 1918 genes. These viruses are generated by Dr. Palese’s lab, in collaboration with Dr. Tumpey, using reverse genetics techniques under high biocontainment level.
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